Tagging to endogenous genes of Plasmodium falciparum using CRISPR/Cas9

RESISTANCE OF PLASMODIUM FALCIPARUM TO CHLOROQUINE IN SOUTH EASTERN IRAN

In vivo and in vitro assessments of the response of P. falciparum to chloroquine using WHO standard kits and techniques were carried out in I ran Shahr, Sistan and Baluchestan province of Iran in 1985. In the in vivo assessment, 24 malaria patients treated with chloroquine (25mg/kg over three days) were followed up for one to four weeks. The mean parasite clearance time was 4.3 days and in...

Finding genes in Plasmodium falciparum.

enough that they might represent two portions of the same gene. Of the 215 protein-coding regions reported by Bowman et al., GlimmerM automatically finds 214 of them. (An earlier version of GlimmerM was provided to the annotators of chromosome 3.) The only gene missed is a short hypothetical protein (PFC0360w, 114 amino acids) with no homology to any known gene. Finally, given that chromosome 3...

Epigenetic Silencing of Plasmodium falciparum Genes Linked to Erythrocyte Invasion

The process of erythrocyte invasion by merozoites of Plasmodium falciparum involves multiple steps, including the formation of a moving junction between parasite and host cell, and it is characterised by the redundancy of many of the receptor-ligand interactions involved. Several parasite proteins that interact with erythrocyte receptors or participate in other steps of invasion are encoded by ...

Detection of Plasmodium falciparum Directly from Blood Samples Using the Polymerase Chain Reaction

Clustering Plasmodium falciparum Genes to their Functional Roles Using k - means

We developed recently a new and novel Metric Matrics k-means (MMk-means) clustering algorithm to cluster genes to their functional roles with a view of obtaining further knowledge on many P. falciparum genes. To further pursue this aim, in this study, we compare three different k-means algorithms (including MMk-means) results from an in-vitro microarray data (Le Roch et al., Science, 2003) with...